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       Jian XU

        xujian@qibebt.ac.cn

       Ph.D., Professor

         Director, Single-Cell Center

        Group Lead, Functional Genomics

         Head, Single-Cell Analysis Section

              Director, Shandong Key Laboratory of Energy Genetics

     


    Biography:

     

    XU Jian received a B.S. in Biotechnology from Peking University in 1997, and a M.S. in Computer Science and a PhD in Biochemistry from Washington University in St. Louis in 2003. After serving as Research Instructor at Genome Institute of Washington University, he joined Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS) in 2008, and has been the founding director of Single-Cell Center (http://www.single-cell.cn/) of QIBEBT. Together with its collaborators, the Center has been developing and demonstrating a new generation of single-cell analysis instruments. Via these innovative research tools, Dr. Xu and his colleagues are delineating and designing key metabolic processes, such as microalgal CO2 fixation, cellulose conversion and human-microbe symbiosis, across the biological hierarchy of single-cell, population and consortium. He has published over 80 papers on peer-reviewed journals such as Science, Cell Host & Microbe, Nature Communications, Nature Plants, PNAS, PLoS Biology, PLoS Genetics, Plant Cell, ISME Journal, Plant Journal, Biotechnology for Biofuels, Analytical Chemistry, Lab on a Chip, etc., with over 4000 citations (for a full list of publications, please see https://www.researchgate.net/profile/Jian_Xu8). He currently serves at the Editorial Boards of mSystems, Scientific Reports and Algal Research. He has won a number of career awards from National Natural Science Foundation of China (NSFC), Ministry of Science and Technology of the People’s Republic of China (MOST) and CAS, including the National Science Fund for Distinguished Young Scholars (2014), National Young-Scientist Award for Science and Technology (2016) and VCANBIO Award for Biosciences and Medicine (2016). He has mentored nearly 20 doctoral students and postdoctoral scholars, and was recognized for excellence in mentorship via the 2013 CAS 100 Best PhD Thesis Award and the 2014 UCAS-BHPB Mentorship Award. Please refer to http://www.single-cell.cn/ for more details. 



    Research Interests: 


    1) Single-cell analysis and instrument development 

    2) Microalgal synthetic biology for carbon dioxide fixation and biofuels

    3) Human microbiota and health


     

    Featured Publication:

     


    1.“Emerging trends for microbiome analysis: from single-cell functional imaging to microbiome big data”, XU J., MA B., SU X., HUANG S., XU X., ZHOU X., HUANG W., KNIGHT R., Engineering, 2017, 3: 66–70

    2.“Label-free, rapid and quantitative phenotyping of stress response via ramanome”, TENG L., WANG X., WANG X., REN L., WANG T., WANG Y., JI Y., HUANG W., XU J., Sci Rep, 2016, DOI:10.1038/srep34359.

    3.“RNAi-based targeted gene-knockdown in model oleaginous microalgae Nannochloropsis spp.”, WEI L., XIN Y., WANG Q., YANG J., HU H., XU J., The Plant Journal, 2016, DOI: 10.1111/tpj.13411.

    4.“Genome editing of model oleaginous microalgae Nannochloropsis spp. by CRISPR/Cas9”, WANG Q., LU Y., XIN Y., WEI L., HUANG S., XU J.,  The Plant Journal, 2016, DOI: 10.1111/tpj.13307.

    5.“Raman activated cell sorting based on dielectrophoretic single-cell trap and release”, ZHANG P., REN L., ZHANG X., SHAN Y., WANG Y., JI Y., YIN H., HUANG W., XU J., MA B., Analytical Chemistry, 2015, DOI: 10.1021/ac503974e.

    6.“Prediction of early childhood caries via spatial-temporal variations of oral microbiota”, TENG F.,YANG F., HUANG S., BO C., XU Z. Z., AMIR A., KNIGHT R., LING J., XU J., Cell Host & Microbe, 2015, 18(3): 296. 

    7.“Cellulosome stoichiometry in clostridium cellulolyticum is regulated by selective rna processing and stabilization”, XU C., HUANG R., TENG L., JING X., HU J., CUI G., WANG Y., CUI Q., XU J., Nature Communications, 2015, 6: 6900. 

    8. “Predictive modeling of gingivitis severity and susceptibility via oral microbiota”, HUANG S., LI R., ZENG X., HE T., ZHAO H., CHANG A., BO C., CHEN J., YANG F., KNIGHT R., LIU J., DAVIS C., XU J., ISME Journal, 2014, 8: 1768. 

    9. “Choreography of transcriptomes and lipidomes of Nannochloropsis reveals the mechanisms of oil synthesis in microalgae”, LI J., HAN D., WANG D., NING K., JIA J., WEI L., JING X., HUANG S., CHEN J., LI Y. et al., Plant Cell, 2014, 26: 1645. 

    10. “Nannochloropsis genomes reveal evolution of microalgal oleaginous traits”, WANG D., NING K., LI J., HU J., HAN D., WANG H., ZENG X., JING X., ZHOU Q., SU X. et al., PLoS Genetics, 2014, 10(1): e1004094. 

    11. “Antagonistic roles of abscisic acid and cytokinin during response to nitrogen depletion in oleaginous microalga Nannochloropsis oceanica expand the evolutionary breadth of phytohormone function”, LU Y., TARKOWSKA D., TURECKOVA V., LUO T. W., XIN Y., LI J., WANG Q. T., JIAO N. Z., STRNAD M., XU J., Plant Journal, 2014, 80: 52. 

    12. “The Thermoanaerobacter glycobiome reveals mechanisms of pentose and hexose co-utilization in bacteria”, LIN L., SONG H., TU Q., QIN Y., ZHOU A., LIU W., HE Z., ZHOU J., XU J., PLoS Genetics, 2011, 7(10): e1002318. 

    13. “Evolution of symbiotic bacteria in the distal human intestine”, XU J., MAHOWALD M. A., LEY R. E., LOZUPONE C. A., HAMADY M., MARTENS E. C., HENRISSAT B., COUTINHO P. M., MINX P., LATREILLE P., CORDUM H., VAN BRUNT A., KIM K., FULTON R. S., FULTON L. A., CLIFTON S. W., WILSON R. K., KNIGHT R. D., GORDON J. I., PLoS Biology, 2007, 5(7): e156. 

    14. “Honor thy symbionts”, XU J., GORDON J. I., Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(18): 10452. 

    15. “A genomic view of the human-Bacteroides thetaiotaomicron symbiosis”, XU J., BJURSELL M. K., HIMROD J., DENG S., CARMICHAEL L. K., CHIANG H. C., HOOPER L. V., GORDON J. I., Science, 2003, 299(5615): 2074. 




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