教育与研究背景

2025.07-今，中国科学院青岛生物能源与过程研究所，博士后

2022.09-2025.06，中国科学院青岛生物能源与过程研究所，博士

2021.07-2022.08，中国科学院青岛生物能源与过程研究所，科研助理

2018.09-2021.07，中国科学院青岛生物能源与过程研究所，生物工程，硕士

2014.09-2018.07，东北农业大学，新能源科学与工程，学士

研究方向

聚焦单细胞高通量筛选关键技术开发，从事液滴微流控、拉曼分选技术等单细胞分析与高通量筛选方向

代表性论文

1. Zhidian Diao#, Qiqun Peng#, Sijun Luo, Lingyan Kan, Anle Ge, Wei Gao, Runxia Li, Weiwei Bao, Xixian Wang, Yuetong Ji, Jian Xu*, Shihui Yang*, Bo Ma*. AI-powered high-throughput digital colony picker platform for sorting microbial strains by multi-modal phenotypes. Nature Communications, 2025, 16: 8769（IF:15.7）

2. Zhidian Diao#, Anle Ge#, Hao Zhou, Xuan Zhou, Lingyan Kan, Wei Gao, Wei Shen, Yuetong Ji, Hongwei Wang, Jian Xu*, Xixian Wang*, Bo Ma*. Rapid quantitative detection,identification and antimicrobial susceptibility testing of pathogens in blood using the static droplet array (SDA) chip-based method. Sensors and Actuators B: Chemical, 2025,442: 138183. （IF:8.4）

3. Zhidian Diao#, Xiaoyan Jing#, Xibao Hou#, Yu Meng, Jiaping Zhang, Yongshun Wang, Yuetong Ji, Anle Ge, Xixian Wang, Yuting Liang*, Jian Xu*, Bo Ma*. Artificial intelligence-assisted automatic Raman-activated cell sorting (AI-RACS) system for mining specific functional microorganisms in the microbiome. Analytical Chemistry, 2024, 96(46):18416-18426. （IF:6.8）

4. Zhidian Diao#, Xixian Wang#, Jiaping Zhang, Anle Ge, Teng Xu, Lingyan Kan, Yuandong Li, Yuetong Ji, Xiaoyan Jing, Jian Xu*, Bo Ma*. Optical-based microbubble for on-demand droplet release from static droplet array (SDA) for dispensing one droplet into one tube. Biosensors and Bioelectronics, 2023, 240: 115639.（IF:12.6）

5. Zhidian Diao#, Lingyan Kan#, Yilong Zhao#, Huaibo Yang, Jingyun Song, Chen Wang, Yang Liu, Fengli Zhang, Teng Xu, Rongze Chen, Yuetong Ji, Xixian Wang, Xiaoyan Jing, Jian Xu, Yuandong Li*, Bo Ma*. Artificial intelligence-assisted automatic and index-based microbial single-cell sorting system for One-Cell-One-Tube. mLife, 2022, 1(4): 448-459. （IF:4.5）

6. Yuanyan Xuan, Meng Yin, Yujiao Sun*, Meijun Liu, Guomin Bai, Zhidian Diao*, Bo Ma, Magnetic nanoparticle-mediated enrichment technology combined with microfluidic single cell separation technology: A technology for efficient separation and degradation of functional bacteria in single cell liquid phase. Bioresource Technology, 2024: 130686. （IF:11.4）

7. Xixian Wang#, Sen Wang#, Zhidian Diao#, Xibao Hou#, Yanhai Gong, Qing Sun, Jiaping Zhang, Lihui Ren, Yuandong Li, Fei Wu, Yuetong Ji, Wei Shen, Yifeng Yin, Shi Huang, Xiaojin Song, Qiu Cui, Yingang Feng*, Jian Xu*, Bo Ma* Label-Free High-Throughput Live-Cell Sorting of Genome-Wide Random Mutagenesis Libraries for Metabolic Traits by Raman Flow Cytometry. Proceedings of the National Academy of Sciences of the United States of America, 2025, 122(22): e2503641122. （IF:9.1）

8. Jia Zhang#*, Jianmei Wang#, Pengfei Zhu#, Zhidian Diao#, Shuhua Tian, Ziyuan Ding, Yongming Duan, Teng Xu, Xuan Zhou, Xixian Wang, Xia Ma, Ting Sun, Xiaoyan Jing, Weilian Hung, Bo Ma, Shi Huang*, Xiaowei Zheng*, Jian Xu*. Raman flow cytometry based single-cell species classification, viable-cell counting and vitality test for probiotic products. iMetaOmics, 2025. e70024.

9. Xiaoyan Jing#, Yanhai Gong#, Zhidian Diao#, Yan Ma#, Yu Meng, Jie Chen, Yishang Ren, Yuting Liang, Yinchao Li, Weihan Sun, Jia Zhang, Yuetong Ji, Zhiqi Cong, Shengying Li, Bo Ma, Zhisong Cui*, Li Ma*, Jian Xu*. Phylogeny-metabolism dual-directed single-cell genomics for dissecting and mining ecosystem function by FISH-scRACS-seq. The Innovation, 2025, 6(3).（IF:33.2）

10. Anle Ge#, Zhidian Diao#, Yuandong Li, Chaojie Cui, Xixian Wang, Yang Liu, Jian Xu*, Bo Ma*, An integrated microfluidic platform for on-demand single droplet dispenser with high accuracy by electrohydrodynamic (EHD) printing technique. Sensors & Actuators B: Chemical, 2024, 405: 135334. （IF:8.4）

11. Xixian Wang#, Lihui Ren#, Zhidian Diao#, Yuehui He#, Jiaping Zhang, Min Liu, Yuandong Li, Lijun Sun, Rongze Chen, Yuetong Ji, Jian Xu*, Bo Ma*. Robust spontaneous Raman flow cytometry for single-cell metabolic phenome profiling via pDEP-DLD-RFC. Advanced Science, 2023, 10(16): e2207497. （IF:15.1）

12. Anle Ge#, Zhidian Diao#, Fengyi Liu, Yuandong Li, Chaojie Cui, Shoujie Li, Yang Liu, Jian Xu, Bo Ma*, Label-free droplet-based bacterial growth phenotype screening by a mini-integrated microfluidic platform. Sensors & Actuators B: Chemical, 2023, 385: 133691. （IF:8.4）（2023年3月22日）

近年主要专利

1. 马波、刁志钿、王喜先、徐腾、徐健，基于光热效应进行微量液滴操控的微流控芯片及方法，ZL202110019705.8（发明专利授权）

2. 马波、刁志钿、葛安乐、徐健，基于电流体动力学的微流控芯片、微量点样装置及方法，ZL202010287622.2（发明专利授权）

3. 马波、刁志钿、王喜先、徐健，一种基于介电确定性位移的细胞分选芯片、装置及方法，ZL202010457651.9（发明专利授权）

4. 马波、刁志钿、王喜先、徐健，一种基于介电确定性位移的细胞分选芯片、装置及方法，7667802（PCT日本发明专利授权）

5. 刁志钿、赵文婕、马波、徐健，一种单细胞捕获方法及微孔耦合微腔室微流控芯片，202411643134.5

6. 刁志钿、刘淑清、马波、徐健，基于微腔室的丝状真菌高通量筛选方法及筛选系统，2025110838545

7. 马波、刁志钿、葛安乐、周浩、徐健，微流控芯片及其制备方法及从全血中快速定量检测和鉴定细菌的方法，202410037373.X

8. 刁志钿、王喜先、张嘉萍、徐健、马波，一种玻璃-镂空薄膜-玻璃的夹心微流控芯片，2023102008007

9. 赵文婕、刁志钿、马波、徐健，基于光操控单细胞和单液滴的方法及微流控芯片